The study investigated the influence of secondary school students’ knowledge on attitude towards environmental pollution in Southwest, Nigeria. The research design for this study was descriptive research of the survey type. The population for this study comprised all senior secondary school students in all the public secondary schools in Southwest, Nigeria. The sample consisted of 2,257 S.S.S.II students and the sample was selected using multistage sampling procedure. The Students’ Environmental Pollution Questionnaire (SEPQ) was used to collect data for the study and it was divided into three sections; A, B, C. The instrument was subjected to face and content validity and it was scrutinise by experts in Science Education and in the area of Tests and Measurement. The reliability of the instrument (SEPQ) was determined by finding the internal consistency through a pilot study. Data collected were analysed using Cronbach’s alpha to determine the internal consistency of the items which yielded co-efficient value of 0.826 for SEPQ. The data collected were analysed using descriptive and inferential statistics. The findings of the study revealed that students’ knowledge of environmental pollution was moderate. However, students’ moderate knowledge did not however influence their attitude towards environmental pollution. In addition, location of students did not influence their attitude towards environmental pollution. It was recommended among others curriculum planners should ensure periodic review of science curriculum by deliberate inclusion of environmental pollution related topics into the school curriculum to enhanced students’ knowledge of the concept.

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