Reported evidence shows that many adolescent girls begin menstruation uninformed and unprepared. However, there is dearth of literature on how educational intervention can help to enhance adolescent girls’ knowledge. Therefore, this study evaluated the effect of nursing intervention on knowledge of menstruation and menstrual hygiene among adolescents in Irepodun-Ifelodun local government of Ekiti State. The study utilized a two- group pre-test post-test quasi-experimental design. Simple random sampling technique was adopted for this study. A structured questionnaire was developed by the researcher and was used to collect pre-test and post-test data on participants’ knowledge. Reliability of the instrument was ascertained using Cronbach Alpha which yielded a co-efficient alpha of 0.79. Data were analyzed using descriptive and inferential statistics. Findings showed that the pre and post intervention mean scores of intervention group were 12.66 and 25.70 respectively with a mean of 13.04 while the pre and post intervention mean scores of control group were 12.51 and 13.45 respectively with the mean gain of only 0.94. There was a significant difference between the pre-and post-test knowledge mean scores in the intervention group (p= 0.000) while there was no significant difference between the pre-and post-test knowledge mean scores in the control group (p= 0.2169). It was recommended among others that similar nurse-led educational intervention should be replicated and implemented in all the secondary schools in Nigeria to systematically enhance adolescents’ knowledge on menstruation and menstrual hygiene.

Keywords: Nursing Intervention, Knowledge, Menstruation, Menstrual Hygiene, Adolescents,

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