The study examined the prevalence of HIV/AIDS Spread in Mufindi District-Iringa Region. It specifically aimed at examining why HIV/AIDS is still a problem in Iringa region and particularly in Mufindi district. There have been a lot of efforts to ensure that there are no new infection but Iringa still holds the first position for almost four years.

This study used cross-sectional research design, and the data collection was based on interview, key informants and focus group discussion. The Data analysis herein employed SPSS for simple descriptive statistics where percentages were generated. The study was undertaken in Mufindi District, whereby the entire sample size of the population was 120 respondents selected randomly. The results show that the use of local brew (45 percent), multiple sex partners and polygamy (24.2 percent) and some specific traditional cultures were the main sources of HIV spread. The major negative effects of HIV which were obtained from the study reveals a state of reduction on individuals income, reduction of individuals production and even poor performance in schools. Generally, HIV is highly affecting people who are poor and those who mostly take on local brew drinking who eventually engage in unsafe sex with multiple sexual partners thus leading to the high levels of HIV spread in Mufindi.

Main Keys: HIV/AIDS, Knowledge, Information, Millennium goals,