Purpose: In the past, 1970’s, researchers and professionals were fascinated with supply chain management as a demanding plan of action for an organization’s resolve and operational performance. Regardless of these, issues relating to persuasive information sharing in the supply chain system to deliver quality pharmaceutical products to clients to prevent deaths remain a challenge. Nevertheless, current literature on information sharing, internal integration and supply chain resilience are insufficient and researchers have complained of its neglect. Accordingly, there is the need for this study to investigate the relationship between information sharing, internal integration, supply chain resilience and operational performance of cold pharmaceutical supplies in Ghana.

Design/Methodology/ Approach: A conceptual model on the use of structural equation modelling (SEM) has been suggested which will be used to quiz the relationship amongst information sharing and operational performance. The current study will use Dynamic capabilities theory (DCT) and Resource-based view (RBV) and postulate a mediated-moderated hypothesis pivoted on positivist stance. The study will also use cross-sectional survey with a census approach with self-administered questionnaire given to suppliers and importers of cold pharmaceutical products in Ghana.

Findings: Extant literature empirically states positive links between information sharing and operational performance. Other studies also revealed different results which show that the relationships though positive, was not strong. In this instance, the introduction of internal integration to improve the effect on the operational performance, is key which serves as an innovative stance.

Originality: The use of supply chain resilience as a moderator between internal integration and operational performance is very new in the cold supply chain systems which brings a great innovation in the cold pharmaceutical product supplies. The authors intend to test this model underpinned by the RBV and DCT lens.

KEYWORDS: Information sharing, operational performance, internal integration, supply chain resilience, cold pharmaceutical products,

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