This study assessed the influence of menopausal-related health symptoms on quality of life of women in Irepodun Local Government Area in Osun State. Descriptive research design of the survey type was adopted in this study. The populations for this study were the women within the age range 45-60 years in six selected wards in Irepodun Local Government. A total of 339 respondents were purposively selected. The research instrument used was a questionnaire tagged Menopausal – Specific Quality of Life Questionnaire which was adapted for the collection of data. The research instrument was validated and reliability index of 0.81 for symptoms of menopause, and 0.89 for Menopause specific quality of life were gotten. Descriptive statistics were used to answer the research questions. Inferential statistics of chi-square was used to test the hypotheses at 0.05 level of significance. The study revealed that menopausal-related health symptoms that women are experiencing are, vasomotor (58.47%), sexual (55.4%), physical (54.87%) and psychosocial (49.23%) domains. A statistically significant relationship was found between vasomotor (X² = 8.881 at P .007), psychological (X² = 18.765 at P = .000), physical (X² = 31.117 at P = .000) and sexual domains (X² = 14.987 at P = .000) domains of menopausal-related health symptoms and quality of life. It was recommended among others that that health care providers need to play a more visible and instrumental role in continuously assessing menopausal women’s needs as well as implement appropriate health education programs for women about the menopausal period and how to pass through it safely.

Keywords: Menopausal-Related, Health Symptoms, Quality of Life, Women,